Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

@article{Ball1997CellcycleAA,
  title={Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1},
  author={Kathryn L. Ball and Sonia Lain and Robin Fahraeus and C. Smythe and D. P. Lane},
  journal={Current Biology},
  year={1997},
  volume={7},
  pages={71-80}
}
BACKGROUND A common event in the development of human neoplasia is the inactivation of a damage-inducible cell-cycle checkpoint pathway regulated by p53. One approach to the restoration of this pathway is to mimic the activity of key downstream effectors. The cyclin-dependent kinase (Cdk) inhibitor p21(WAF1) is one such molecule, as it is a major mediator of the p53-dependent growth-arrest pathway, and can, by itself, mediate growth suppression. The primary function of the p21(WAF1) protein… CONTINUE READING
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Crystal structure of the p 27 Kip 1 cyclindependentkinase inhibitor bound to the cyclin A – Cdk 2 complex

  • AA Russo, PD Jeffrey, J PattenAKMassague, NP Pavletich
  • Nature
  • 1996

Lane DP: Human and plant proliferating-cell nuclear antigen share a highly conserved binding specificity for the p53inducible gene product p21WAF1

  • KL Ball
  • Eur J Biochem
  • 1996
2 Excerpts

Pavletich NP: Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A–Cdk2 complex

  • AA Russo, PD Jeffrey, J Patten AK Massague
  • Nature
  • 1996

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