Cell cycle and developmental control of hematopoiesis by Runx1.

  title={Cell cycle and developmental control of hematopoiesis by Runx1.},
  author={Alan D Friedman},
  journal={Journal of cellular physiology},
  volume={219 3},
Runx1 binds DNA in cooperation with CBFbeta to activate or repress transcription, dependent upon cellular context and interaction with a variety of co-activators and co-repressors. Runx1 is required for emergence of adult hematopoietic stem cells (HSC) during embryonic development and for lymphoid, myeloid, and megakaryocyte lineage maturation from HSC in adult marrow. Runx1 levels vary during the cell cycle, and Runx1 regulates G1 to S cell cycle progression. Both Cdk and ERK phosphorylate… CONTINUE READING
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