Cell cycle and death control: long live Forkheads.

  title={Cell cycle and death control: long live Forkheads.},
  author={Boudewijn M. T. Burgering and Geert J. P. L. Kops},
  journal={Trends in biochemical sciences},
  volume={27 7},
The FOXO family of Forkhead transcription factors, FKHR (FOXO1), FKHR-L1 (FOXO3a) and AFX (FOXO4), are regulated by the phosphoinositide-3-kinase-protein-kinase-B (PI3K-PKB/c-Akt) pathway. Direct phosphorylation by PKB results in cytoplasmic retention and inactivation, inhibiting the expression of FOXO-regulated genes, which control the cell cycle, cell death, cell metabolism and oxidative stress. This pathway appears to be well conserved throughout evolution. In the nematode Caenorhabditis… CONTINUE READING
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