Cell cycle–regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation

@inproceedings{Zheng2014CellCM,
  title={Cell cycle–regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation},
  author={Zhen Zheng and Qingwen Wan and Gerry Meixiong and Quansheng Du},
  booktitle={Molecular biology of the cell},
  year={2014}
}
Accurate and efficient separation of sister chromatids during anaphase is critical for faithful cell division. It has been proposed that cortical dynein-generated pulling forces on astral microtubules contribute to anaphase spindle elongation and chromosome separation. In mammalian cells, however, definitive evidence for the involvement of cortical dynein in chromosome separation is missing. It is believed that dynein is recruited and anchored at the cell cortex during mitosis by the α subunit… CONTINUE READING

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Cytoskeletal dynamics: A view from the membrane

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