Cell cultures in uterine leiomyomas: rapid disappearance of cells carrying MED12 mutations.

@article{Markowski2014CellCI,
  title={Cell cultures in uterine leiomyomas: rapid disappearance of cells carrying MED12 mutations.},
  author={Dominique Nadine Markowski and Mahboobeh Tadayyon and Sabine Bartnitzke and Gazanfer Belge and Burkhard Maria Helmke and Joern Bullerdiek},
  journal={Genes, chromosomes & cancer},
  year={2014},
  volume={53 4},
  pages={317-23}
}
Uterine leiomyomas (UL) are the most frequent symptomatic human tumors. Nevertheless, their molecular pathogenesis is not yet fully understood. To learn more about the biology of these common neoplasms and their response to treatment, cell cultures derived from UL are a frequently used model system, but until recently appropriate genetic markers confirming their origin from the tumor cell population were lacking for most UL, i.e., those not displaying karyotypic abnormalities. The… CONTINUE READING
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