Cell culture-derived Babesia bovis vaccine: sequential challenge exposure of protective immunity during a 6-month postvaccination period.

@article{Kuttler1983CellCB,
  title={Cell culture-derived Babesia bovis vaccine: sequential challenge exposure of protective immunity during a 6-month postvaccination period.},
  author={K. L. Kuttler and Michael G. Levy and Mihailo Ristic},
  journal={American journal of veterinary research},
  year={1983},
  volume={44 8},
  pages={1456-9}
}
Cell culture-derived soluble Babesia bovis vaccine admixed with a saponin adjuvant was administered in 2 doses, 3 weeks between doses, to 18 yearling heifers. An additional 9 heifers served as nonvaccinated controls. Comparable groups of these animals were challenge exposed at 131 and 178 days after vaccination, using 1 X 10(8) B bovis organisms contained in freshly collected blood from a splenectomized calf with ascending parasitemia. Challenge exposure led to no deaths of vaccinated animals… CONTINUE READING