Cell culture: building a better matrix

@article{Blow2009CellCB,
  title={Cell culture: building a better matrix},
  author={Nathan S. Blow},
  journal={Nature Methods},
  year={2009},
  volume={6},
  pages={619-622}
}
  • N. Blow
  • Published 1 August 2009
  • Biology, Engineering
  • Nature Methods
With the realization that cells interact extensively with their surrounding microenvironments during growth and development, the challenge for researchers has become designing three-dimensional culture systems that more closely mimic those relationships. 
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3D capillary beds in an in vitro microfluidic platform that is comprised of a biocompatible collagen I gel supported by a mechanical framework of alginate beads are reported, offering a modular method to encapsulate and co-culture cells that either promote angiogenesis or require perfusion for cell viability in engineered tissue constructs.
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