Cell cooperation and role of the P2X₇ receptor in pulmonary inflammation induced by nanoparticles.

@article{Dekali2013CellCA,
  title={Cell cooperation and role of the P2X₇ receptor in pulmonary inflammation induced by nanoparticles.},
  author={Samir Dekali and Ariane Divetain and Thierry Kortulewski and Justine Vanbaelinghem and Christelle Gamez and Françoise Rogerieux and Ghislaine Lacroix and Patrice Rat},
  journal={Nanotoxicology},
  year={2013},
  volume={7 8},
  pages={1302-14}
}
Macrophages and alveolar epithelial cells are the first targets of inhaled nanoparticles (NPs) reaching the alveoli. Mono- or co-cultures of lung epithelial (A549 or NCI-H441) and macrophage (THP-1) cell lines were used to study the cell cooperation and the involvement of the P2X₇ cell death receptor during the inflammation caused by SiO₂ and TiO₂ NPs. Here we show that, secretion of pro-inflammatory cytokines (IL-1β, IL-6 and IL-8) in response to NPs exposure was higher in co-cultures than in… CONTINUE READING