Cell contacts in human islets of Langerhans.

  title={Cell contacts in human islets of Langerhans.},
  author={Lelio Orci and Francine Malaisse-Lagae and Myl{\`e}ne Amherdt and Mariella Ravazzola and A Weisswange and Rebecca Dobbs and Alain Perrelet and Roger H. Unger},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={41 5},
The freeze-fracturing technique was applied to fresh human islets of Langerhans. With this technique, the inside of cellular membranes was revealed, and specific membrane differentiations, hitherto unknown, were observed in the plasma membrane of the endocrine cells. The specific membrane differentiations represent two types of intercellular junctions, namely the tight junction, which determines a closure of the extracellular space and the gap junction which allows molecules and ions to diffuse… CONTINUE READING

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