Cell-cell signaling during synapse formation in the CNS.

  title={Cell-cell signaling during synapse formation in the CNS.},
  author={Peter Scheiffele},
  journal={Annual review of neuroscience},
Synapses join individual nerve cells into a functional network. Specific cell-cell signaling events regulate synapse formation during development and thereby generate a highly reproducible connectivity pattern. The accuracy of this process is fundamental for normal brain function, and aberrant connectivity leads to nervous system disorders. However, despite the overall precision with which neuronal circuits are formed, individual synapses and synaptic networks are also plastic and can readily… CONTINUE READING
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