Cell-cell membrane fusion during mammalian fertilization.

  title={Cell-cell membrane fusion during mammalian fertilization.},
  author={Paul Primakoff and Diana Gold Myles},
  journal={FEBS letters},
  volume={581 11},
The mechanism of sperm-egg fusion in mammals is a research area that has greatly benefited from the use of gene deletion technology. Because fertilization is internal in mammals and the gametes (particularly the eggs) are sparse in number, in vitro studies have considerable limitations. Using gene deletions, a few cell surface proteins in both gametes have been identified as essential for gamete fusion. Ongoing studies are directed at analysis of the function of these proteins and the search… CONTINUE READING

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