Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans.

  title={Cell-cell interactions prevent a potential inductive interaction between soma and germline in C. elegans.},
  author={Geraldine Seydoux and Tim Schedl and Iva Greenwald},
  volume={61 6},
In each gonadal arm of wild-type C. elegans hermaphrodites, the somatic distal tip cell (DTC) maintains distal germline nuclei in mitosis, while proximal nuclei enter meiosis. We have identified two conditions under which a proximal somatic cell, the anchor cell (AC), inappropriately maintains proximal germline nuclei in mitosis: when defined somatic gonadal cells have been ablated in wild type, and in lin-12 null mutants. Laser ablations and mosaic analysis indicate that somatic gonadal cells… CONTINUE READING

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