Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody

@article{Imhof1983CellcellIA,
  title={Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody},
  author={Beat A Imhof and Heinz Peter Vollmers and Simon L. Goodman and Walter Birchmeier},
  journal={Cell},
  year={1983},
  volume={35},
  pages={667-675}
}
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148 Citations
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148 Citations

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Citation Type

Epithelial cell adhesion molecules.
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Monoclonal antibodies against rat liver plasma membranes, that inhibited the adhesion of mouse metastatic TA3 mammary carcinoma cells to rat hepatocytes in vitro, indicate that the OPAR antigen is different from other hepatic adhesion molecules.
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JAM-2, a Novel Immunoglobulin Superfamily Molecule, Expressed by Endothelial and Lymphatic Cells*
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The results suggest that JAM-2 is a novel vascular molecule, which participates in interendothelial junctional complexes, and the role of the protein in the sealing of cell-cell contact is suggested.
The Structure and Function of Cell Adhesion Molecules
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
TLDR
It is shown that nontransformed Madin-Darby canine kidney epithelial cells acquire invasive properties when intercellular adhesion is specifically inhibited by the addition of antibodies against the cell adhesion molecule uvomorulin; the separated cells then invade collagen gels and embryonal heart tissue.
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A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide
TLDR
A functional assay has been developed to identify cell surface proteins involved in the formation of epithelial tight junctions and the role of uvomorulin-like and liver cell adhesion molecule (L-CAM)-like polypeptides in the establishment of the epithelial occluding barrier is discussed.
Antagonistic effects of laminin and fibronectin in cell-to-cell and cell-to-matrix interactions in MCF-7 cultures
TLDR
Antilaminin antibodies inhibited cluster formation and attachment, emphasizing the important role of this glycoprotein not only in promoting cluster attachment but also in cell-to-cell contact formation in tumor progression and metastasis.
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