Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases.

@article{Sirn2006CellcellCA,
  title={Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases.},
  author={Vappu Sir{\'e}n and Pertteli Salmenper{\"a} and Esko Kankuri and Jozef B{\'i}zik and Timo Sorsa and Taina I Tervahartiala and Antti Vaheri},
  journal={Annals of medicine},
  year={2006},
  volume={38 3},
  pages={212-20}
}
BACKGROUND We recently found that direct homotypic cell-cell contacts between human dermal fibroblasts induce a novel form of cell activation leading to non-apoptotic programmed cell death. As the major features of this process we identified massive induction of cyclo-oxygenase-2 and production of inflammatory prostaglandins. On the surface of the decomposing spheroids, activation of the major extracellular proteolytic cascade, plasminogen activation, associated with surface exposure of alpha… CONTINUE READING

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Fibroblast activation in vascular inflammation.

Journal of thrombosis and haemostasis : JTH • 2011

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