Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

@article{BenZeev1988CellcellAC,
  title={Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.},
  author={Avri Ben-Ze'ev and Gregory S. Robinson and Nancy L. R. Bucher and Stephen R. Farmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 7},
  pages={
          2161-5
        }
}
Freshly isolated adult rat hepatocytes exhibit a flat, extended morphology when cultured on dried rat tail collagen in the presence of growth factors; they actively synthesize DNA and express high levels of cytoskeletal mRNAs and proteins (actin, tubulin, cytokeratins, vinculin, alpha-actinin, and desmoplakin), while exhibiting low levels of liver-specific mRNAs (albumin, alpha 1-inhibitor III, and alpha 1-antitrypsin) and limited synthesis and secretion of albumin. Hepatocytes cultured on… CONTINUE READING

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