Cell calcium, oncogenes, and hypertrophy.

@article{Marbn1990CellCO,
  title={Cell calcium, oncogenes, and hypertrophy.},
  author={Eduardo Marb{\'a}n and Yukihiro Koretsune},
  journal={Hypertension},
  year={1990},
  volume={15 6 Pt 1},
  pages={652-8}
}
The cellular mechanisms of cardiac hypertrophy remain unclear despite tantalizing clues gleaned from a variety of experimental approaches. Here we examine the hypothesis that an increase in cytosolic free Ca2+ concentration ([Ca2+]i) triggers the expression of proto-oncogenes, which in turn direct the characteristic increase in protein synthesis. New results from perfused ferret hearts are presented demonstrating that [Ca2+]i increases as a direct consequence of an elevation in perfusion… CONTINUE READING

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