Cell biology and physiology of CLC chloride channels and transporters.

@article{Stauber2012CellBA,
  title={Cell biology and physiology of CLC chloride channels and transporters.},
  author={Tobias Stauber and Stefanie Weinert and Thomas J Jentsch},
  journal={Comprehensive Physiology},
  year={2012},
  volume={2 3},
  pages={1701-44}
}
Proteins of the CLC gene family assemble to homo- or sometimes heterodimers and either function as Cl(-) channels or as Cl(-)/H(+)-exchangers. CLC proteins are present in all phyla. Detailed structural information is available from crystal structures of bacterial and algal CLCs. Mammals express nine CLC genes, four of which encode Cl(-) channels and five… CONTINUE READING