Cell biology: Tubulin acetylation and cell motility.

  title={Cell biology: Tubulin acetylation and cell motility.},
  author={Alexander F Palazzo and Brian Ackerman and G. Gundersen},
Tubulin acetylation: responsible enzymes, biological functions and human diseases
It is concluded that tubulin acetylation is important for regulating microtubule architecture and maintainingmicrotubule integrity and together with detyrosination, glutamylation and other modifications, tubulinacetylation may form a unique ‘language’ to regulate microtubules structure and function. Expand
Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.
A role for Wnt/PCP signaling in orchestrating the complex organization and dynamics of the fiber cell cytoskeleton in the mammalian lens is supported. Expand
Distinct contributions of microtubule subtypes to cell membrane shape and stability.
Stiffness is shown to depend on the interplay between dynamically unstable MTs, stable MTs and IFs which all act to impart a distinct cellular type of transient "metastability". Expand
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions
A scenario in which the decreased dynamics of hyperacetylated microtubules in HDAC6-inhibited cells compromises their capacity to mediate the focal adhesion dynamics required for rapid cell migration is suggested. Expand
Posttranslational modifications of the cytoskeleton
An overview of the major PTMs that occur on the main structural components of the three cytoskeletal systems—tubulin, actin, and intermediate filament proteins—and highlight the cellular function of these modifications is provided. Expand
SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa
Testing the efficacy of SAHA for its ability to protect photoreceptors in in-vitro and in-situ models of RP found it to protect mitochondria from damage, and concomitantly reduced photoreceptor cell death in cell and organ cultures. Expand
Targeting Histone Modifications in Bone and Lung Metastatic Cancers
It is shown that HDAC inhibitors in combination with bone protective therapies may be beneficial in the treatment of bone metastatic cancers, and preclinical studies have shown that these drugs can reduce distant metastasis by targeting molecular factors and signaling pathways that drive tumor cell dissemination to these sites. Expand
p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation
Overall, in response to glucose starvation, p27 promotes autophagy by facilitating autophagosome trafficking along microtubule tracks by maintaining elevatedmicrotubule acetylation via an ATAT1-dependent mechanism. Expand
Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport
It is shown that EHV-1 activates the small GTPases Rac1 and Cdc42 during infection, which is necessary for virus-induced acetylation of tubulin, effective viral transport to the nucleus, and cell-to-cell spread. Expand
Pin1 coordinates HDAC6 upregulation with cell migration in lung cancer cells
The data suggest that Pin1 acts as an important regulator to manage HDAC6 expression for cell motility in lung cancer cells. Expand