Cell biology, chemogenomics and chemoproteomics – application to drug discovery

@article{Gagna2007CellBC,
  title={Cell biology, chemogenomics and chemoproteomics – application to drug discovery},
  author={Claude E. Gagna and W. Clark Lambert},
  journal={Expert Opinion on Drug Discovery},
  year={2007},
  volume={2},
  pages={381 - 401}
}
Cell biology has added immensely to the understanding of basic biologic concepts. However, scientists need to use cell biology more in the proteomic–genomic revolution. The authors have developed two novel techniques: transitional structural chemogenomics (TSCg) and transitional structural chemoproteomics (TSCp). TSCg is used to regulate gene expression by using ultrasensitive small-molecule drugs that target nucleic acids. By using chemicals to target transitional changes in the helical… Expand
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References

SHOWING 1-10 OF 101 REFERENCES
Chemical genomics: a systematic approach in biological research and drug discovery.
TLDR
Chemical genomics or chemogenomics is a new term that describes the development of target-specific chemical ligand and the use of such chemical ligands to globally study gene and protein functions and it is anticipated that chemical genomics plays a critical role in the genomic age of biological research and drug discovery. Expand
Chemoproteomics as a basis for post-genomic drug discovery.
TLDR
Chemoproteomics--the use of biological information to guide chemistry--offers a highly efficient alternative to small-molecule characterization that can accelerate drug discovery in the post-genomic era. Expand
Chemical genomics in the global study of protein functions.
Small, cell-permeable and target-specific chemical ligands offer great therapeutic value. They can also be used to dissect diverse biological processes, such as cellular metabolism, signalExpand
DNA array-based gene profiling: from surgical specimen to the molecular portrait of cancer.
TLDR
The technical features characterizing this powerful laboratory tool are discussed and the applications so far described in the field of oncology are reviewed, with revolutionary implications for the clinical management of patients with cancer. Expand
Chemical proteomics and its application to drug discovery.
TLDR
The multidisciplinary science of chemical proteomics makes use of synthetic small molecules that can be used to covalently modify a set of related enzymes and subsequently allow their purification and/or identification as valid drug targets to accelerate the often difficult process of target validation and drug discovery. Expand
Proteomic Tools for Cell Biology
TLDR
This review will present a general overview of the currently available proteomic tools and then give examples of how these tools are being utilized to answer questions in cell biology. Expand
Cell biology, chemogenomics and chemoproteomics
TLDR
The scientific techniques used in molecular biological research and drug discovery have changed dramatically over the past 10 years due to the influence of genomics, proteomics and bioinformatics, resulting in a new scientific approach called chemogenomics. Expand
Chromatin immunoprecipitation assay.
TLDR
The critical parameters and the variants of ChiP as well as the different analytical tools that can be combined with ChIP to enable better understanding of DNA-protein interactions in vivo are addressed. Expand
Genomics and proteomics tools for the clinic.
  • F. Rudert
  • Biology, Medicine
  • Current opinion in molecular therapeutics
  • 2000
TLDR
The chip principle has now become the dominating theme for a number of new genomics and proteomics technologies, culminating in the lab-on-a-chip concept which, in the next five to ten years, could advance at a comparable rate to that of computers over the last 50 years. Expand
Proteomics: a powerful tool in the post-genomic era.
TLDR
The technology and its applications in plant sciences are discussed, including photosynthesis investigations and proteomics, analysis of the protein complement of the genome. Expand
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3
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