Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis.

@article{Gelse2008CellbasedRO,
  title={Cell-based resurfacing of large cartilage defects: long-term evaluation of grafts from autologous transgene-activated periosteal cells in a porcine model of osteoarthritis.},
  author={K Gelse and Christiane Muehle and Oliver Franke and Jung Ju Park and Marc Jehle and Karsten Durst and Mathias G{\"o}ken and Friedrich Hennig and Klaus von der Mark and Holm Schneider},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 2},
  pages={475-88}
}
OBJECTIVE To investigate the potential of transgene-activated periosteal cells for permanently resurfacing large partial-thickness cartilage defects. METHODS In miniature pigs, autologous periosteal cells stimulated ex vivo by bone morphogenetic protein 2 gene transfer, using liposomes or a combination of adeno-associated virus (AAV) and adenovirus (Ad) vectors, were applied on a bioresorbable scaffold to chondral lesions comprising the entire medial half of the patella. The resulting repair… CONTINUE READING

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