Cell-based quantification of molecular biomarkers in histopathology specimens.

@article{AlKofahi2011CellbasedQO,
  title={Cell-based quantification of molecular biomarkers in histopathology specimens.},
  author={Yousef Al-Kofahi and Wiem Lassoued and Kedar Grama and Sumit Kumar Nath and Jianliang Zhu and Ridha Oueslati and Michael Feldman and William M. F. Lee and Badrinath Roysam},
  journal={Histopathology},
  year={2011},
  volume={59 1},
  pages={40-54}
}
AIMS To investigate the use of a computer-assisted technology for objective, cell-based quantification of molecular biomarkers in specified cell types in histopathology specimens, with the aim of advancing current visual estimation and pixel-level (rather than cell-based) quantification methods. METHODS AND RESULTS Tissue specimens were multiplex-immunostained to reveal cell structures, cell type markers, and analytes, and imaged with multispectral microscopy. The image data were processed… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…