Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.

@article{Hatano2013CellbasedMO,
  title={Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells.},
  author={Hiroyu Hatano and Vivek Jain and Peter W. Hunt and Tzong-Hae Lee and Elizabeth Sinclair and T. P. D. Do and Rebecca A. Hoh and Jeffrey N Martin and Joseph M McCune and Frederick M. Hecht and Michael P. Busch and Steven G. Deeks},
  journal={The Journal of infectious diseases},
  year={2013},
  volume={208 1},
  pages={50-6}
}
BACKGROUND  Studies aimed at defining the association between host immune responses and human immunodeficiency virus (HIV) persistence during therapy are necessary to develop new strategies for cure. METHODS  We performed a comprehensive assessment of ultrasensitive plasma HIV RNA levels, cell-associated HIV RNA levels, proviral HIV DNA levels, and T cell immunophenotyping in a cohort of 190 subjects in whom HIV levels were suppressed by highly active antiretroviral therapy. RESULTS  The… CONTINUE READING
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