Cell-based high-content screening of small-molecule libraries.

  title={Cell-based high-content screening of small-molecule libraries.},
  author={Kerstin Korn and Eberhard Krausz},
  journal={Current opinion in chemical biology},
  volume={11 5},
Advanced microscopy and the corresponding image analysis have been developed in recent years into a powerful tool for studying molecular and morphological events in cells and tissues. Cell-based high-content screening (HCS) is an upcoming methodology for the investigation of cellular processes and their alteration by multiple chemical or genetic perturbations. Multiparametric characterization of responses to such changes can be analyzed using intact live cells as reporter. These disturbances… CONTINUE READING

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