Cell based approaches for evaluation of drug-induced liver injury.

  title={Cell based approaches for evaluation of drug-induced liver injury.},
  author={Mhairi L Greer and Jane Barber and Julie A Eakins and John Gerry Kenna},
  volume={268 3},
An improved understanding of mechanisms that underlie drug-induced liver injury (DILI) is required to enable design of drugs that have minimal potential to cause this adverse reaction in man. Available evidence suggests DILI arises in susceptible patients because of an imbalance between chemical insults (which are an inherent property of certain drugs and/or their metabolites) and the ability of the liver to mount compensatory/adaptive responses. In vivo safety testing in pre-clinical species… CONTINUE READING


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