Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor

@article{Lau2016CellbasedAI,
  title={Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor},
  author={Aik Jiang Lau and Regina Politi and Guixiang Yang and Thomas K. H. Chang},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2016},
  volume={163},
  pages={59-67}
}
It has been reported that quercetin is an activator of rat vitamin D receptor (rVDR). However, the conclusion was based on experiments performed without all the appropriate control groups, raising the possibility of a false-positive finding. Furthermore, distinct differences exist in the chemical structures of quercetin and 1α,25-dihydroxyvitamin D3, which is a prototypic agonist of VDR. Therefore, we investigated systematically whether quercetin and other flavonols are agonists of rVDR, mouse… CONTINUE READING
BETA
1
Twitter Mention

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Z

X. E. Zheng
  • Wang, M.Z. Liao, Y.S. Lin, M.C. Shuhart, E.G. Schuetz, K.E. Thummel, Human PXR-mediated induction of intestinal CYP3A4 attenuates 1,25dihydroxyvitamin D3 function in human colon adenocarcinoma LS180 cells, Biochem. Pharmacol. 84
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL