Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.

@article{Centanin2008CellAO,
  title={Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.},
  author={L{\'a}zaro Centanin and Andr{\'e}s Dekanty and Nuria Magdalena Romero and Maximiliano Irisarri and Thomas A Gorr and Pablo Wappner},
  journal={Developmental cell},
  year={2008},
  volume={14 4},
  pages={547-58}
}
Drosophila tracheal terminal branches are plastic and have the capacity to sprout out projections toward oxygen-starved areas, in a process analogous to mammalian angiogenesis. This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells. Here, we show that extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on the HIF-prolyl hydroxylase Fatiga that operates as an oxygen sensor. In mild… CONTINUE READING
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