Cell-autonomous signal transduction in the Xenopus egg Wnt/β-catenin pathway

@inproceedings{Motomura2014CellautonomousST,
  title={Cell-autonomous signal transduction in the Xenopus egg Wnt/β-catenin pathway},
  author={Eriko Motomura and Tomohiro Narita and Yuya Nasu and Hirotaka Kato and Ayako Sedohara and Shin-ichiro Nishimatsu and Masttkazu Sakai},
  booktitle={Development, growth & differentiation},
  year={2014}
}
Wnt proteins are thought to bind to their receptors on the cell surfaces of neighboring cells. Wnt8 likely substitutes for the dorsal determinants in Xenopus embryos to dorsalize early embryos via the Wnt/β-catenin pathway. Here, we show that Wnt8 can dorsalize Xenopus embryos working cell autonomously. Wnt8 mRNA was injected into a cleavage-stage blastomere, and the subcellular distribution of Wnt8 protein was analyzed. Wnt8 protein was predominantly found in the endoplasmic reticulum (ER) and… CONTINUE READING

Figures and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

by contact between the cortical dorsal determinant and the equatorial core cytoplasm in eggs of Xenopus laevis

K. Katsumoto, T. Arikawa, +3 authors M. Sakai
  • 2004
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL