Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.

@article{Mulholland2011CellAR,
  title={Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.},
  author={David J. Mulholland and Linh M. Tran and Yunfeng Li and Houjian Cai and Ashkan Morim and Shunyou Wang and Seema B. Plaisier and Isla P. Garraway and Jiaoti Huang and Thomas G Graeber and Hong Wu},
  journal={Cancer cell},
  year={2011},
  volume={19 6},
  pages={792-804}
}
Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not clear. Here, we show that castration-resistant growth is an intrinsic property of Pten null prostate cancer (CaP) cells, independent of cancer development stage. PTEN loss suppresses androgen-responsive gene expressions by modulating androgen receptor (AR) transcription factor activity. Conditional deletion of Ar in the… CONTINUE READING
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