Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch.

@article{Schilder2012CellautonomousRO,
  title={Cell-autonomous regulation of fast troponin T pre-mRNA alternative splicing in response to mechanical stretch.},
  author={Rudolf J Schilder and Scot R. Kimball and Leonard S. Jefferson},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={303 3},
  pages={C298-307}
}
How mechanochemical signals induced by the amount of weight borne by the skeletal musculature are translated into modifications to muscle sarcomeres is poorly understood. Our laboratory recently demonstrated that, in response to experimentally induced increases in the weight load borne by a rat, alternative splicing of the fast skeletal muscle troponin T (Tnnt3) pre-mRNA in gastrocnemius was adjusted in a correlated fashion with the amount of added weight. (Schilder RJ, Kimball SR, Marden JH… CONTINUE READING
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  • 2011

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