Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

@article{Verd1999CellautonomousRO,
  title={Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB},
  author={Javier Verd{\'u} and Michael A. Buratovich and Elizabeth L. Wilder and Morris J Birnbaum},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={500-506}
}
Organismal size is determined by a tightly regulated mechanism that coordinates cell growth, cell proliferation and cell death. The Drosophila insulin receptor/Chico/Dp110 pathway regulates cell and organismal size. Here we show that genetic manipulation of the phosphoinositide-3-OH-kinase-dependent serine/threonine protein kinase Akt (protein kinase B) during development of the Drosophila imaginal disc affects cell and organ size in an autonomous manner. Ectopic expression of Akt does not… CONTINUE READING
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