Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis.

@article{Rallis2010CellautonomousIC,
  title={Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis.},
  author={Charalampos Rallis and Sheena M. Pinchin and D. Ish-Horowicz},
  journal={Development},
  year={2010},
  volume={137 21},
  pages={
          3591-601
        }
}
Integrins act at signalling crossroads, and their interactions with other signal transduction pathways are key to the regulation of normal and pathological cell cytoarchitecture and behaviour. Here, we describe a signalling cascade that acts during the formation of the defining segmental features of the vertebrate body - the somites - in which β1-integrin activity regulates epithelialisation by controlling downstream Wnt and Notch activity crucial for somite border formation. Using in vivo… CONTINUE READING

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