Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus.

  title={Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus.},
  author={C{\'a}tia M. Teixeira and Michelle Marie Kron and Nuria Masachs and Helen Zhang and Diane C. Lagace and Albert Martinez and Isabel Reillo and Xin Duan and Carles Bosch and Llu{\'i}s Pujadas and Lucas Brunso and Hongjun Song and Amelia J Eisch and V{\'i}ctor Borrell and Brian W Howell and Jack M. Parent and Eduardo Soriano},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={32 35},
Adult hippocampal neurogenesis is thought to be essential for learning and memory, and has been implicated in the pathogenesis of several disorders. Although recent studies have identified key factors regulating neuroprogenitor proliferation in the adult hippocampus, the mechanisms that control the migration and integration of adult-born neurons into circuits are largely unknown. Reelin is an extracellular matrix protein that is vital for neuronal development. Activation of the Reelin cascade… CONTINUE READING
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