Cell autonomous commitment to an endodermal fate and behaviour by activation of Nodal signalling.

@article{David2001CellAC,
  title={Cell autonomous commitment to an endodermal fate and behaviour by activation of Nodal signalling.},
  author={Nicolas B David and Fr{\'e}d{\'e}ric Marc Rosa},
  journal={Development},
  year={2001},
  volume={128 20},
  pages={3937-47}
}
In vertebrates the endoderm germ layer gives rise to most tissues of the digestive tract and controls head and heart morphogenesis. The induction of endoderm development relies on extracellular signals related to Nodals and propagated intracellularly by TGFbeta type I receptors ALK4/Taram-A. It is unclear, however, whether Nodal/ALK4/Taram-A signalling is involved only in the specification of endodermal precursors or plays a more comprehensive role in the activation of the endodermal program… CONTINUE READING
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