Cell-autonomous PrP-Doppel interaction regulates apoptosis in PrP gene-deficient neuronal cells.

@article{Sakudo2005CellautonomousPI,
  title={Cell-autonomous PrP-Doppel interaction regulates apoptosis in PrP gene-deficient neuronal cells.},
  author={Akikazu Sakudo and Deug-Chan Lee and Izuru Nakamura and Yojiro Taniuchi and Keiichi Saeki and Yoshitsugu Matsumoto and Shigeyoshi Itohara and Kazuyoshi Ikuta and Takashi Onodera},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 2},
  pages={448-54}
}
The Prnd-encoded prion protein (PrP)-like protein, Doppel (Dpl), is a homologue of Prnp-encoded PrP, and is N-glycosylated protein with glycosylphosphatidylinositol anchor like PrP. Recently, ectopic expressions of Prnp/Prnd chimeric mRNAs have been identified as the cause of late-onset ataxia observed in several lines of Prnp-knockout mice such as ZrchII, Ngsk, Rcm0, and Rikn mice. However, it remains unclear whether the toxic effect of Dpl expression is a cell-autonomous mechanism but rather… CONTINUE READING

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