Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling.

@article{Bao2002CellAT,
  title={Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling.},
  author={Wenjie Bao and Minna Thullberg and Hongquan Zhang and Anatoli Onischenko and Staffan Str{\"o}mblad},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 13},
  pages={4587-97}
}
The cyclin-dependent kinase 2 (Cdk2) inhibitors p21(CIP1) and p27(KIP1) are negatively regulated by anchorage during cell proliferation, but it is unclear how integrin signaling may affect these Cdk2 inhibitors. Here, we demonstrate that integrin ligation led to rapid reduction of p21(CIP1) and p27(KIP1) protein levels in three distinct cell types upon attachment to various extracellular matrix (ECM) proteins, including fibronectin (FN), or to immobilized agonistic anti-integrin monoclonal… CONTINUE READING