Cell attachment to microcarriers affects growth, metabolic activity, and culture productivity in bioreactor culture.

Abstract

It is not well understood how changes from suspension to microcarrier cultures affect cell growth, metabolism, and yield of recombinant proteins. To investigate the effects of culture conditions on cell characteristics, fed-batch bioreactor cultures were performed under different culture conditions (suspension cultures, cultures attached to Cytodex 3 and… (More)

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