Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo.

@article{Li2001CellassociatedOI,
  title={Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo.},
  author={Man-xiang Li and Gayle M Davey and Robyn M. Sutherland and Christian Kurts and Andrew M Lew and Cheryl Hirst and Francis Robert Carbone and William R Heath},
  journal={Journal of immunology},
  year={2001},
  volume={166 10},
  pages={
          6099-103
        }
}
To better understand the antigenic requirements for cross-presentation, we compared the in vivo efficiency of presentation of cell-associated vs soluble OVA with the OT-I (CD8) and OT-II (CD4) TCR transgenic lines. Cross-presentation of cell-associated OVA was very efficient, requiring as little as 21 ng of OVA to activate OT-II cells and 100-fold less to activate OT-I cells. In contrast, soluble OVA was presented inefficiently, requiring at least 10,000 ng OVA for activation of either T cell… CONTINUE READING
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