Cell and tissue responses to oxidative damage.

  title={Cell and tissue responses to oxidative damage.},
  author={Yvonne M. W. Janssen and Bennett van Houten and Paul J A Borm and Brooke T. Mossman},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={69 3},
A broad array of oxidative stresses modulates gene expression in a variety of mammalian cells. One goal of this review was to characterize cellular responses to oxidative injury, how these processes are regulated, and the outcome for a particular cell or tissue. Many genes induced in response to specific oxidant stresses have been identified and include transcription factors, replication proteins, proteases, protease inhibitors, proteins affecting cell proliferation and various antioxidants, i… CONTINUE READING
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