Cell and Tissue Destruction in Selected Disorders

  title={Cell and Tissue Destruction in Selected Disorders},
  author={Jürgen Arnhold},



Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Novel antioxidants have shown great potential in mediating disease phenotypes and could be an area of interest for further research, as well as a highlight on the antioxidant-based therapies for alleviating disease severity.

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

How cell-intrinsic changes in important structural cells can perpetuate the fibrotic response by regulating the differentiation, recruitment, proliferation and activation of extracellular matrix–producing myofibroblasts is described.

Pathology and disease mechanisms in different stages of multiple sclerosis

  • H. Lassmann
  • Biology, Psychology
    Journal of the Neurological Sciences
  • 2013

Inflammation in wound repair: molecular and cellular mechanisms.

Cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair are reviewed and a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response is provided.

Crohn's disease

Oxidative stress in the pathogenesis of diabetic neuropathy.

Evidence is presented to support the idea that both chronic and acute hyperglycemia cause oxidative stress in the peripheral nervous system that can promote the development of diabetic neuropathy, and it is concluded that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients.

Crohn disease: A current perspective on genetics, autophagy and immunity

It is hoped that an improved understanding of pathogenic mechanisms, for example by studying the genetic basis of CD and other forms of inflammatory bowel diseases (IBD), will lead to improved therapies and possibly preventative strategies in individuals identified as being at risk.

Transfusion-Related Acute Lung Injury: The Work of DAMPs*

  • W. Land
  • Biology, Medicine
    Transfusion Medicine and Hemotherapy
  • 2013
Evidence has been collected in support of the notion that the transfusion-related acute lung injury induces a ‘sterile’ inflammation in the lung of transfused patients in terms of an acute innate inflammatory disease.

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

Understanding the pathways involved in excitotoxic mechanisms and how they are involved in the pathogenesis of neurodegenerative diseases is of critical importance for the future clinical treatment of many neurodegening diseases.