Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins.

@article{GarciaGuzman1999CellAR,
  title={Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins.},
  author={Miguel Garcia-Guzman and Fabrizio Dolfi and Maurizio Russello and Kristiina Vuori},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 9},
  pages={5762-8}
}
Integrin ligand binding induces a signaling complex formation via the direct association of the docking protein p130(Cas) (Cas) with diverse molecules. We report here that the 14-3-3zeta protein interacts with Cas in the yeast two-hybrid assay. We also found that the two proteins associate in mammalian cells and that this interaction takes place in a phosphoserine-dependent manner, because treatment of Cas with a serine phosphatase greatly reduced its ability to bind 14-3-3zeta. Furthermore… CONTINUE READING

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