Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry.

@article{Brunton2004CellAR,
  title={Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry.},
  author={Valerie G Brunton and Iain R Macpherson and Margaret C Frame},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1692 2-3},
  pages={121-44}
}
The interaction of cells with surrounding matrix and neighbouring cells governs many aspects of cell behaviour. Aside from transmitting signals from the external environment, adhesion receptors also receive signals from the cell interior. Here we review the interrelationship between adhesion receptors, tyrosine kinases (both growth factor receptor and non-receptor) and modulators of the actin cytoskeletal network. Deregulation of many aspects of these signalling pathways in cancer highlights… CONTINUE READING

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