Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly.

@article{Thomas2002CellAM,
  title={Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly.},
  author={Alan J Thomas and I. Nicol Ferrier and Rajesh N. Kalaria and Sue Davis and John T. O'Brien},
  journal={The British journal of psychiatry : the journal of mental science},
  year={2002},
  volume={181},
  pages={
          129-34
        }
}
BACKGROUND Neuroimaging studies have demonstrated changes in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in major depression. AIMS We investigated the expression of cell adhesion molecules (CAMs) in the prefrontal cortex in depression. METHOD Immunohistochemistry to localise CAMs in post-mortem tissue from 20 subjects with major depression and 20 controls, and image analysis to quantify their expression. RESULTS We found significant increases in CAMs in… CONTINUE READING

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