Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

@article{Cavallaro2004CellAA,
  title={Cell adhesion and signalling by cadherins and Ig-CAMs in cancer},
  author={Ugo Cavallaro and Gerhard Christofori},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={118-132}
}
In addition to their adhesive functions, cell-adhesion molecules modulate signal-transduction pathways by interacting with molecules such as receptor tyrosine kinases, components of the WNT signalling pathway and RHO-family GTPases. So, changes in the expression of cell-adhesion molecules affect not only the adhesive repertoire of a cell, but also its signal-transduction status. Conversely, signalling pathways can modulate the function of cell-adhesion molecules, altering the interactions… 

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