Cell adhesion and migration properties of beta 2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation.

@article{Sixt2001CellAA,
  title={Cell adhesion and migration properties of beta 2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation.},
  author={Michael Sixt and Rupert Hallmann and Olaf Wendler and Karin Scharffetter-Kochanek and Lydia M Sorokin},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={18878-87}
}
Regulated adhesion of leukocytes to the extracellular matrix is essential for transmigration of blood vessels and subsequent migration into the stroma of inflamed tissues. Although beta(2)-integrins play an indisputable role in adhesion of polymorphonuclear granulocytes (PMN) to endothelium, we show here that beta(1)- and beta(3)-integrins but not beta(2)-integrin are essential for the adhesion to and migration on extracellular matrix molecules of the endothelial cell basement membrane and… CONTINUE READING