Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.

@article{Gottlieb1995CellAI,
  title={Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.},
  author={Roberta A Gottlieb and H A Giesing and Jia Zhu and Robert L. Engler and Bernard M. Babior},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 13},
  pages={5965-8}
}
Neutrophils in tissue culture spontaneously undergo programmed cell death (apoptosis), a process characterized by well-defined morphological alterations affecting the cell nucleus. We found that these morphological changes were preceded by intracellular acidification and that acidification and the apoptotic changes in nuclear morphology were both delayed by granulocyte colony-stimulating factor (G-CSF). Among the agents that defend neutrophils against intracellular acidification is a vacuolar H… CONTINUE READING
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