Cell Type Specific Analysis of Human Brain Transcriptome Data to Predict Alterations in Cellular Composition.

@article{Xu2013CellTS,
  title={Cell Type Specific Analysis of Human Brain Transcriptome Data to Predict Alterations in Cellular Composition.},
  author={Xiaoxiao Xu and Arye Nehorai and Joseph D Dougherty},
  journal={Systems biomedicine},
  year={2013},
  volume={1 3},
  pages={151-160}
}
The central nervous system (CNS) is composed of hundreds of distinct cell types, each expressing different subsets of genes from the genome. High throughput gene expression analysis of the CNS from patients and controls is a common method to screen for potentially pathological molecular mechanisms of psychiatric disease. One mechanism by which gene expression might be seen to vary across samples would be alterations in the cellular composition of the tissue. While the expressions of gene… CONTINUE READING

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