Cell-Surface labeling and internalization by a fluorescent inhibitor of prostate-specific membrane antigen.

@article{Liu2008CellSurfaceLA,
  title={Cell-Surface labeling and internalization by a fluorescent inhibitor of prostate-specific membrane antigen.},
  author={Tiancheng Liu and Lisa Y. Wu and Marat Kazak and Clifford E. Berkman},
  journal={The Prostate},
  year={2008},
  volume={68 9},
  pages={
          955-64
        }
}
BACKGROUND [corrected] Prostate-specific membrane antigen (PSMA) remains an attractive target for imaging and therapeutic applications for prostate cancer. Recent efforts have been made to conjugate inhibitors of PSMA with imaging agents. Compared to antibodies, small-molecule inhibitors of PSMA possess apparent advantages for in vivo applications. To date, there are no reports on the cellular fate of such constructs once bound the extracellular domain of PSMA. The present study was focused on… CONTINUE READING

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