Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

@inproceedings{Matheson2015CellSP,
  title={Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef},
  author={Nicholas J Matheson and Jonathan C. Sumner and Kim Wals and Radu Rapiteanu and Michael P Weekes and Raphael Vigan and Julia Weinelt and Michael Schindler and Robin Antrobus and Ana S. H. Costa and Christian Frezza and Clary B Clish and Stuart J. D. Neil and Paul J Lehner},
  booktitle={Cell host & microbe},
  year={2015}
}
Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a comprehensive, unbiased overview of how HIV infection remodels the T cell surface, we took a distinct, systems-level, quantitative proteomic approach. >100 plasma membrane proteins, many without characterized immune functions, were downregulated during HIV infection. Host factors targeted by the viral accessory proteins Vpu or Nef… CONTINUE READING
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