Cell Surface Associated Alpha-l-Fucose Moieties Modulate Human Breast Cancer Neoplastic Progression

Abstract

Glycosylation drives critical processes important for mammalian cell–cell and cell–matrix interactions. Alpha-l-fucose (α-l-f) is a key monosaccharide component of oligosaccharides that has been found to be overexpressed during tumor progression. Modification of cell surface fucosylation, we hypothesized, alters tumor cell phenotype and function at the end… (More)
DOI: 10.1007/s12253-008-9036-x

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