Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-β by Activin and Gonadotropin-Releasing Hormone in the LβT2 Pituitary Gonadotrope Cell Model.

@article{Pernasetti2001CellSpecificTR,
  title={Cell-Specific Transcriptional Regulation of Follicle-Stimulating Hormone-β by Activin and Gonadotropin-Releasing Hormone in the LβT2 Pituitary Gonadotrope Cell Model.},
  author={Flavia Pernasetti and Vyacheslav V Vasilyev and Suzanne B Rosenberg and Janice S Bailey and H J Huang and William L. Miller and Pamela L Mellon},
  journal={Endocrinology},
  year={2001},
  volume={142 6},
  pages={2284-2295}
}
FSH is secreted by gonadotropes of the anterior pituitary and plays a crucial role in mammalian reproduction. However, little is known about FSH gene regulation due to the lack of a gonadotrope cell line that synthesizes FSH. The LbT2 mouse pituitary cell line, isolated by targeted tumorigenesis in transgenic mice, has the characteristics of a mature gonadotrope, including expression of GnRH receptor, steroidogenic factor 1, and both the aand b-subunits of LH, but was thought not to express FSH… CONTINUE READING

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